IGG100 Ga-68 Generator

Cyclotron-independent production of the positron emitter 68Gallium

Features

IGG100 68Ge/68Ga Generator (Chemical Grade)

Cyclotron-independent production of the positron emitter 68Gallium

The Eckert & Ziegler Isotope Products (EZIP) Ionic Gallium Generator is a closed system consisting of a borosilicate glass column containing a titanium dioxide bed on which 68Ge is absorbed. 68Ga is continuously produced by decay of its radioactive parent and is eluted with 0.1 M HCI. This generator is designed to minimize both 68Ge breakthrough and metal impurities in the eluate. The elution profile of the IGG100 68Ge/68Ga generator has been optimized for maximum activity concentration per volume. To improve safety, reliability and simplicity, the IGG100 requires no disassembly. It is shipped ready-to-use. Both, the inlet and outlet lines use Luer female connections with attached caps for easy installation. EZIP maintains a comprehensive quality and regulatory compliance program based on a number of industry standards and regulations ensuring the production of consistently high quality products. The IGG100 68Ge/68Ga generator device is made according to these regulated standards and good practices.

The IGG100 68Ge/68Ga generator is a chemical grade product and not intended for use in humans. It has not been validated as a pharmaceutical product.

 

Description
The Eckert & Ziegler Isotope Products (EZIP) Ionic 68Gallium Generator is a device to obtain the positron emitter 68Gallium, independent of a cyclotron. The generator is a closed system consisting of a borosilicate glass column containing a titanium dioxide bed on which 68Ge is adsorbed. 68Ga is continuously produced by decay of its radioactive parent 68Ge and is eluted with 0.1 M HCl. EZIP maintains a comprehensive quality and regulatory compliance program based on a number of industry standards and regulations ensuring the production of consistently high quality products. The IGG100 68Ge/68Ga generator device is made according to these regulated standards and good practices. The generator is available with the following activities: 10 mCi, 20 mCi, 30 mCi, 40 mCi and 50 mCi.

Output
A new generator in full equilibrium typically yields approximately 65 % – 70 % 68Ga or better for each elution. In practice, a generator requires at Ieast 7 hours to achieve full yield after being eluted. Output, of course, will decrease with decay of the 68Ge parent.

Advantages
EZIP’s IGG100 68Ge/68Ga generator is ready-to-use as a standalone device and is fully shielded. The IGG100 can be easily handled and installed due to its small size and light weight.
There is no metal in contact with the eluate. It can be implemented in the Modular-Lab synthesis system for research applications with 68Ga-peptides and is eluted fully automatic therein.

Multi Generator Elution Tool
Up to three IGG100 68Ge/68Ga generators (each max. 1.85 GBq/50 mCi) can be eluted automatically by using Eckert & Ziegler Eurotope’s Multi Generator Elution Tool. The tool updates the currently available activity within each of the generators so the user only needs to enter the required amount of activity via the included software tool. It automatically calculates the theoretically available activity in each referenced generator, based on the date of its previous elution. The tool furthermore gives recommendation as to which generator(s) should be eluted in order to provide the requested activity. Users can either accept or manually select another option.